https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55734  6 ppm. Lung function data from healthy infants (age 5–9 weeks) born to asthmatic mothers and parent-reported respiratory questionnaire data aged 12 months were collected in the Breathing for Life Trial (BLT) birth cohort. Tidal breathing analysis and SF6-based Multiple Breath Washout testing were performed in quiet sleep. Descriptive statistics and regression analysis were used to assess associations. Results: Data were collected on 423 participants. Infants born to women who self-reported smoking during pregnancy (n = 42) had higher lung clearance index (LCI) than those born to nonsmoking mothers (7.90 vs. 7.64; p = .030). Adjusted regression analyzes revealed interactions between self-reported smoking and LCI (RR: 1.98, 95% CI: 1.07–3.63, 0.028, for each unit increase in LCI) and between eCO > 6 ppm and LCI (RR: 2.25, 95% CI: 1.13–4.50, 0.022) for the risk of wheeze in the first year of life. Conclusion: In utero tobacco smoke exposure induces lung ventilation inhomogeneities. Furthermore, an interaction between smoke exposure and lung ventilation inhomogeneities increases the risk of having a wheeze in the first year of life.]]> Wed 19 Jun 2024 09:54:57 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14519 Wed 11 Apr 2018 13:27:14 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10921 Sat 24 Mar 2018 08:10:56 AEDT ]]>